pentobarbital will reduce the level or outcome of diazepam buccal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Potent or reasonable CYP3A4 inducers could boost charge of diazepam elimination; hence, efficacy of diazepam might be lessened.
pentobarbital will increase effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Warning/Observe. Coadministration of ifosfamide with CYP2B6 inducers may well improve metabolism of ifosfamide to its metabolite. Keep track of for amplified effects/toxicities if mixed with CYP2B6 inducers.
pentobarbital will lessen the extent or impact of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will minimize the level or influence of phenytoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep track of.
pentobarbital will minimize the level or effect of carbamazepine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Comment: Barbiturates may improve adverse effects, which include respiratory despair, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates raise metabolism and decrease blood concentrations of TCAs.
Prevent; coadministration with CYP3A inducers may well end in reduced plasma concentrations of elvitegravir and/or perhaps a concomitantly administered protease inhibitor and bring on loss of therapeutic outcome and also to doable resistance
pentobarbital will lower the level or impact of donepezil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unknown.
pentobarbital will decrease the level or influence of eltrombopag by influencing hepatic enzyme CYP2C9/10 metabolism. Use Caution/Watch.
pentobarbital will decrease the extent or influence of celecoxib by impacting hepatic enzyme CYP2C9/10 metabolism. Minor/Importance Unknown.
fentanyl transmucosal and pentobarbital both increase sedation. Stay clear of or Use Alternate Drug. Restrict use to individuals for whom different therapy alternatives are insufficient
pentobarbital will minimize the level or impact of ondansetron by influencing more info hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. No dosage adjustment for ondansetron is usually recommended for clients on these drugs.
pentobarbital will reduce the extent or influence of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Impact of coadministering a strong CYP3A4 inducer with fedratinib hasn't been analyzed.
fentanyl iontophoretic transdermal method and pentobarbital the two increase sedation. Stay clear of or Use Alternate Drug. Restrict use to people for whom alternative treatment method alternatives are insufficient